The relevant principles under Article 2 of the Convention concerning the State’s obligations in the area of healthcare can be found in Makharadze and Sikharulidze v.

  42184/09, §   146, 11   December   2014; Makharadze and Sikharulidze v. Georgia , no.   35254/07, §   90, 22   November 2011; and Gladkiy v.

  42184/09, §   146, 11 December 2014; Makharadze and Sikharulidze v. Georgia , no.   35254/07, §   90, 22   November 2011; and Gladkiy v.

dies as a result of a health problem, the State must offer a reasonable explanation as to the cause of death and the treatment administered to the person concerned prior to his or her death (see Makharadze

of the present case, in addressing all aspects of the applicant’s complaint under Article 2 of the Convention and in rectifying matters through the domestic legal system (compare and contrast with Makharadze

of the Convention, the Court must examine whether the relevant domestic authorities did everything reasonably possible, in good faith and in a timely manner, to try to avert the fatal outcome (see Makharadze

    As regards the Government’s plea as to non-exhaustion, having regard to the Court’s case-law on the subject (see Goginashvili , cited above, §§   51 ‑ 60; and Makharadze and Sikharulidze

Georgia (no. 47729/08 , §§   32 ‑ 35, 4 October 2011), and Makharadze and Sikharulidze v.   Georgia   (no. 35254/07 , §§ 40-43, 22 November 2011). THE LAW I.

Georgia , no. 47729/08, §§ 51-61, 4 October 2011, and Makharadze and Sikharulidze v. Georgia , no. 35254/07, §§   53 ‑ 55, 22   November 2011).

  47729/08, §§   69-70, 4   October 2011, and Makharadze and Sikharulidze v.   Georgia , no.

99, ECHR 2009 (extracts)), the existence of a preventive remedy is indispensable for the effective protection of individuals against the kind of treatment prohibited by Article   3 (see also Makharadze

Makharadze, a lawyer practising in Tbilisi. 3.     The Government were represented by their Agent, Mr B. Dzamashvili, of the Ministry of Justice. 4.

  Georgia , no.47729/08, § 49, 4   October 2011, Makharadze and Sikharulidze v. Georgia , no.35254/07, §   52, 22 November 2011 and Čuprakovs v.